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In this drug factsheet:
- How does this medication work? What will it do for me?
- How should I use this medication?
- What form(s) does this medication come in?
- Who should NOT take this medication?
- What side effects are possible with this medication?
- Are any nutrients depleted by this medication?
- Are there any other precautions or warnings for this medication?
- What other drugs could interact with this medication?
DIN (Drug Identification Number)
|02268493||GLUMETZA 500 MG Extended release tablet|
|02300451||GLUMETZA 1000 MG Extended release tablet|
Metformin works by reducing the amount of glucose made by the liver and by making it easier for glucose to enter into the tissues of the body. Metformin has been found to be especially useful in delaying problems associated with diabetes for overweight people with diabetes.
This medication may be available under multiple brand names and/or in several different forms. Any specific brand name of this medication may not be available in all of the forms or approved for all of the conditions discussed here. As well, some forms of this medication may not be used for all of the conditions discussed here.
Your doctor may have suggested this medication for conditions other than those listed in these drug information articles. If you have not discussed this with your doctor or are not sure why you are taking this medication, speak to your doctor. Do not stop taking this medication without consulting your doctor.
Do not give this medication to anyone else, even if they have the same symptoms as you do. It can be harmful for people to take this medication if their doctor has not prescribed it.
The recommended starting dose of metformin extended release tablets for adults is 1,000 mg once daily, to be taken with food in the evening. The maximum daily dose should not exceed 2,000 mg once daily. Metformin may be used alone or with other medications that reduce blood sugar. To ensure that the medication is working well, monitor your blood glucose on a regular basis as directed by your doctor or diabetes educator.
Many things can affect the dose of medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are taking the medication without consulting your doctor.
It is important to take this medication exactly as prescribed by your doctor. If you miss a dose, take it as soon as possible and continue with your regular schedule. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice.
Store this medication at room temperature, protect it from light and moisture, and keep it out of the reach of children.
Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.
Each white, film-coated, oval-shaped tablet, debossed with "M 500", contains metformin HCl 500 mg. Nonmedicinal ingredients: hypromellose, microcrystalline cellulose, magnesium stearate, polyethylene glycol, polysorbate, titanium dioxide, and polyethylene oxide.
Each white, oval-shaped tablet, printed with "M 1000" contains metformin HCl 1000 mg. Nonmedicinal ingredients: colloidal silicon dioxide, crospovidone, glyceryl behenate, polyvinyl alcohol, polyacrylate dispersion, hypromellose, talc, polyethylene glycol, titanium dioxide, simethicone emulsion, polysorbate, shellac glaze, iron oxide black, macrogol, n-butyl alcohol, propylene glycol, FD&C Blue No. 2, FD&C Yellow No. 6, and FD&C Red No. 40.
Do not take this medication if you:
- are allergic to metformin or any ingredients of this medication
- are experiencing or recovering from severe infections, trauma, or surgery
- are pregnant or breast-feeding
- are suffering severe dehydration (have lost a lot of water from your body)
- are undergoing radiologic studies involving use of iodinated contrast materials
- drink large amounts of alcohol in the short term or on a regular basis
- have a history of lactic acidosis or acute/chronic metabolic acidosis (too much acid in the blood), diabetic ketoacidosis with or without coma, or history of ketoacidosis with or without coma
- have diseases associated with lack of oxygen to the tissues such as cardio-respiratory insufficiency
- have reduced kidney function
- have severe liver disease
- have type 1 diabetes (people with type 1 diabetes should always be using insulin)
- have very poor blood glucose control (these people should not take this medication as the only antidiabetic agent)
Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent.
The side effects listed below are not experienced by everyone who takes this medication. If you are concerned about side effects, discuss the risks and benefits of this medication with your doctor.
The following side effects have been reported by at least 1% of people taking this medication. Many of these side effects can be managed, and some may go away on their own over time.
Contact your doctor if you experience these side effects and they are severe or bothersome. Your pharmacist may be able to advise you on managing side effects.
- loss of appetite
- metallic taste in mouth
- passing of gas
- stomach ache
- weight loss
Although most of the side effects listed below don't happen very often, they could lead to serious problems if you do not check with your doctor or seek medical attention.
Check with your doctor as soon as possible if any of the following side effects occur:
- low blood sugar (mild), including:
- behavioural changes similar to being drunk
- blurred vision
- cold sweats
- cool, pale skin
- difficulty concentrating
- excessive hunger
- fast heartbeat
- restless sleep
- slurred speech
Stop taking the medication and seek immediate medical attention if any of the following occur:
- lactic acidosis (quick and severe), including:
- fast, shallow breathing
- muscle pain or cramping
- slow or irregular heartbeat
- unusual sleepiness
- unusual stomach ache (after the initial stomach ache that can occur at the start of therapy)
- unusual tiredness or weakness
Some people may experience side effects other than those listed. Check with your doctor if you notice any symptom that worries you while you are taking this medication.
Some medications can affect vitamin and nutrient levels in the body. Below is a list of nutrient depletions associated with this medication. Talk to your doctor or pharmacist about whether taking a supplement is recommended or if you have any questions or concerns.
Glumetza may deplete vitamin B12
How can this nutrient deficiency impact me?
Vitamin B12, also known as cyancobalamin or cobalamin, is involved in the body's metabolism, DNA synthesis, and red blood cells. It also helps maintain the nervous system. Vitamin B12 deficiency is most common in people on meatless diets since it is not found in grains, fruits, or vegetables. Talk to your Rexall™ Pharmacist about vitamin B12 deficiency. Vitamin B12 is available as a supplement, such as Be Better Vitamin B12. Before starting any nutrient supplement, always talk with your Rexall™ Pharmacist.
Glumetza may deplete folic acid
How can this nutrient deficiency impact me?
Folic acid is a nutrient that is vital to the production and development of new cells, especially during pregnancy. It is important for the production, repair, and functioning of DNA for all cells. Folic acid deficiency is a serious concern during pregnancies since it increases the risk of birth defects such as spina bifida and cleft palate. Anemia can also occur due to folic acid deficiency. Folic acid is available in a supplement, such as Rexall™ Folic Acid. Before starting any nutrient supplement, always talk with your Rexall™ Pharmacist.
Before you begin taking a medication, be sure to inform your doctor of any medical conditions or allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should take this medication. \ Alcohol intake: Anyone taking metformin should avoid excessive alcohol intake.
Blood sugar control: If you have fever, trauma, infection, or surgery, you may have a temporary loss of blood sugar control. At such times, your doctor may think it is necessary to stop metformin and temporarily inject insulin. Metformin may be started again after the problem is resolved.
Blood sugar monitoring: Monitor your blood sugar regularly at intervals as discussed with your doctor or diabetes educator.
Diabetes complications: The use of metformin (or any other medication used for diabetes) will not prevent the development of complications particular to diabetes mellitus (e.g., kidney disease, nerve disease, eye disease).
Diet: Metformin is a treatment to be taken in combination with a proper diet. Metformin is not a substitute for proper diet.
Dye or contrast agents: If you are going to have an X-ray procedure that uses dye or a contrast agent, you may need to stop taking this medication for a short time. Contact your doctor for instructions.
Kidney problems: If you have kidney problems, your doctor should closely monitor your condition while you are taking metformin, as it may affect kidney function.
Lactic acidosis: Lactic acidosis is a rare but serious problem that occurs due to metformin accumulation (i.e., the body doesn't get rid of it fast enough) during treatment. If you have severe kidney disease you are at higher risk of developing lactic acidosis. Since alcohol may increase the risk of lactic acidosis, do not drink a lot of alcohol over the short- or long-term while taking this medication. When it does occur (very rarely), it is fatal in 50% of cases. There have been no reports of lactic acidosis in Canada when metformin was used as directed. If you experience symptoms of lactic acidosis (e.g., weakness, tiredness, drowsiness, unusual muscle pain, trouble breathing, stomach pain with nausea, vomiting or diarrhea, feeling cold, dizziness, light-headedness, or slow or irregular heartbeat), stop taking this medication and get immediate medical attention.
Liver function: Decreased liver function has been linked to lactic acidosis. This medication is not recommended for people with severely reduced liver function. If you have moderately reduced liver function, discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed.
Low blood sugar: Under usual circumstances, low blood sugar does not occur for people who take only metformin. Low blood sugar could occur when not enough food is eaten, especially when strenuous exercise is undertaken at the same time or when large amounts of alcohol have been consumed.
Reduced response: Over a period of time, you may become progressively less responsive to a particular treatment for diabetes because your diabetes worsens. If metformin fails to lower blood sugar to target levels, talk to your doctor. Your doctor may want to stop metformin or recommend another medication.
Surgery: This medication should be stopped temporarily for surgery (except for minor surgery where food and fluid intake is not restricted). You will be restarted on this medication once you are eating and drinking and your kidney function has been tested and is normal. Talk to your doctor for specific instructions.
Vitamin B12 levels: This medication may decrease vitamin B12 levels. Your doctor will monitor your B12 levels with blood tests while you are taking this medication.
Pregnancy: This medication should not be used during pregnancy. If you become pregnant while taking this medication, contact your doctor immediately.
Breast-feeding: Metformin is believed to pass into breast milk. This medication should not be used if you are breast-feeding.
Children: The safety and effectiveness of this medication have not been established for children.
Seniors: Kidney function often decreases with age. As a result, seniors may be more likely to experience side effects of this medication.
There may be an interaction between metformin and any of the following:
If you are taking any of these medications, speak with your doctor or pharmacist. Depending on your specific circumstances, your doctor may want you to:
- stop taking one of the medications,
- change one of the medications to another,
- change how you are taking one or both of the medications, or
- leave everything as is.
An interaction between two medications does not always mean that you must stop taking one of them. Speak to your doctor about how any drug interactions are being managed or should be managed.
Medications other than those listed above may interact with this medication. Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.
All material copyright MediResource Inc. 1996 – 2018. Terms and conditions of use. The contents herein are for informational purposes only. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition. Source: www.medbroadcast.com/drug/getdrug/Glumetza
All material © 1996-2018 MediResource Inc. Terms and conditions of use. The contents herein are for informational purposes only. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition.
This medication may be causing nutrient depletion.
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