Ubrelvy

Brand Name

Ubrelvy

Common Name

ubrogepant

In this drug factsheet:

• How does this medication work? What will it do for me?
• How should I use this medication?
• What form(s) does this medication come in?
• Who should NOT take this medication?
• What side effects are possible with this medication?
• Are there any other precautions or warnings for this medication?
• What other drugs could interact with this medication?

How does this medication work? What will it do for me?

Ubrogepant belongs to the class of medications called calcitonin gene-related peptide (CGRP) receptor antagonists. It is used to treat migraines that occur with or without aura. Ubrogepant is not intended to prevent migraines.

Ubrogepant works by blocking the activity of a protein called calcitonin gene-related peptide. For people suffering a migraine attack, this protein is released by the nerves and causes increased pain. This medication prevents the CGRP from binding to pain receptors in the brain.

This medication may be available under multiple brand names and/or in several different forms. Any specific brand name of this medication may not be available in all of the forms or approved for all of the conditions discussed here. As well, some forms of this medication may not be used for all of the conditions discussed here.

Your doctor may have suggested this medication for conditions other than those listed in these drug information articles. If you have not discussed this with your doctor or are not sure why you are taking this medication, speak to your doctor. Do not stop taking this medication without consulting your doctor.

Do not give this medication to anyone else, even if they have the same symptoms as you do. It can be harmful for people to take this medication if their doctor has not prescribed it.

How should I use this medication?

The recommended dose of ubrogepant is 50 mg or 100 mg taken by mouth. If the first dose does not relieve symptoms, a second dose may be taken 2 hours later. A second dose may also be used if the migraine is relieved but then returns. The maximum dose is 200 mg during any 24-hour period. The safety of taking more than 16 doses in a 30-day period is not known. For this reason, no more than 16 doses should be taken in a month. If you need to take this medication more frequently, contact your doctor.

Ubrogepant may be taken with or without food. Grapefruit or grapefruit juice should be avoided as ubrogepant may build up in the body and cause an increase in side effects.

Many things can affect the dose of medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are taking the medication without consulting your doctor.

Store this medication at room temperature, protect it from light and moisture, and keep it out of the reach of children.

Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.

What form(s) does this medication come in?

50 mg
Each white-to-off-white, capsule-shaped, biconvex tablet debossed with “U50” on one side, contains 50 mg of ubrogepant. Nonmedicinal ingredients: colloidal silicon dioxide, croscarmellose sodium, mannitol, microcrystalline cellulose, polyvinylpyrrolidone/vinyl acetate copolymer, sodium chloride, sodium stearyl fumarate, vitamin E polyethylene glycol succinate.

100 mg
Each white-to-off-white, capsule-shaped, biconvex tablet debossed with “U100” on one side, contains 100 mg of ubrogepant. Nonmedicinal ingredients: colloidal silicon dioxide, croscarmellose sodium, mannitol, microcrystalline cellulose, polyvinylpyrrolidone/vinyl acetate copolymer, sodium chloride, sodium stearyl fumarate, vitamin E polyethylene glycol succinate.

Who should NOT take this medication?

Do not take this medication if you:

are allergic to ubrogepant or any ingredients of the medication

are taking any of the following medications:

• clarithromycin
• itraconazole
• ketoconazole

What side effects are possible with this medication?

Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent.

The side effects listed below are not experienced by everyone who takes this medication. If you are concerned about side effects, discuss the risks and benefits of this medication with your doctor.

The following side effects have been reported by at least 1% of people taking this medication. Many of these side effects can be managed, and some may go away on their own over time.

Contact your doctor if you experience these side effects and they are severe or bothersome. Your pharmacist may be able to advise you on managing side effects.

• dry mouth
• nausea
• sleepiness

Stop taking the medication and seek immediate medical attention if any of the following occur:

• signs of a serious allergic reaction (e.g., abdominal cramps, difficulty breathing, nausea and vomiting, or swelling of the face and throat)

Some people may experience side effects other than those listed. Check with your doctor if you notice any symptom that worries you while you are taking this medication.

Are there any other precautions or warnings for this medication?

Before you begin using a medication, be sure to inform your doctor of any medical conditions or allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use this medication.

Birth control: Ubrogepant may decrease the effectiveness of hormonal birth control, such as birth control pills. If you use birth control pills as contraception, a second method of birth control, such as condoms, should also be used,

Drowsiness/reduced alertness: Ubrogepant may cause sleepiness, affecting your ability to drive or operate machinery. Avoid driving, operating machinery, or performing other potentially hazardous tasks until you have determined how you are affected by this medication.

Liver function:  Liver disease or reduced liver function may cause this medication to build up in the body, causing side effects. If you have liver problems, discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed.

Pregnancy: This medication should not be used during pregnancy unless the benefits outweigh the risks. If you become pregnant while taking this medication, contact your doctor immediately.

Breast-feeding: It is not known if ubrogepant passes into breast milk. If you are breast-feeding and are taking this medication, it may affect your baby. Talk to your doctor about whether you should continue breast-feeding.

Children: The safety and effectiveness of using this medication have not been established for children.

Seniors: The effects of this medication on seniors have not been well studied. It is likely that people over the age of 65 will experience more side effects due to the increased likelihood of decreased kidney or liver function. Report any unusual effects to your doctor as soon as possible.

What other drugs could interact with this medication?

There may be an interaction between ubrogepant and any of the following:

• alprazolam
• amiodarone
• amlodipine
• apalutamide
• aprepitant
• “azole” antifungals (e.g., itraconazole, ketoconazole, voriconazole)
• bicalutamide
• birth control pills
• bosentan
• carvedilol
• cimetidine
• ciprofloxacin
• clopidogrel
• cobicistat
• conivaptan
• cyclosporine
• CF transmembrane regulators (e.g., elexacaftor, ivacaftor, lumacaftor, tezacaftor)
• danazol
• deferasirox
• dexamethasone
• diltiazem
• dronedarone
• echinacea
• elagolix
• eliglustat
• eltrombopag
• enzalutamide
• everolimus
• febuxostat
• flibanserin
• fluvoxamine
• fostemsavir
• gingko biloba
• grapefruit juice
• hepatitis C antivirals (e.g., elbasvir and grazoprevir, ledipasvir, voxilaprevir)
• HIV non-nucleoside reverse transcriptase inhibitors (NNRTIs; e.g., efavirenz, etravirine, nevirapine)
• HIV protease inhibitors (e.g., atazanavir, darunavir, lopinavir, ritonavir)
• isoniazid
• leflunomide
• letermovir
• lomitapide
• lurasidone
• macrolide antibiotics (e.g., azithromycin, clarithromycin, erythromycin)
• mifepristone
• modafinil
• nirmatrelvir and ritonavir
• pitolisant
• propiverine
• protein kinase inhibitors (e.g., ceritinib, imatinib, lapatinib, nilotinib, osimertinib, pazopanib)
• rifabutin
• rifampin
• seizure medications (e.g., carbamazepine, clobazam, eslicarbazepine, oxcarbazepine, phenobarbital, phenytoin, rufinamide)
• spironolactone
• tafamidis
• tecovirimat
• telotristat
• teriflunomide
• tocilizumab
• upadacitinib
• verapamil

If you are taking any of these medications, speak with your doctor or pharmacist. Depending on your specific circumstances, your doctor may want you to:

• stop taking one of the medications,
• change one of the medications to another,
• change how you are taking one or both of the medications, or
• leave everything as is.

An interaction between two medications does not always mean that you must stop taking one of them. Speak to your doctor about how any drug interactions are being managed or should be managed.

Medications other than those listed above may interact with this medication. Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.

All material copyright MediResource Inc. 1996 – 2024. Terms and conditions of use. The contents herein are for informational purposes only. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition. Source: www.medbroadcast.com/drug/getdrug/Ubrelvy