What Are the Causes of HIV?
The virus can be found in the blood, semen, vaginal fluid, and breast milk of infected people. HIV is also found in saliva, sweat, and tears, though not in high enough amounts to transmit the virus to another person. HIV does not transmit through sneezing, shaking hands, or from toilet seats or mosquito bites.
The 2 most common ways to be infected with HIV in North America are through unprotected vaginal, anal, or oral sex and by sharing needles. Although the risk of infection is lower with oral sex, it is still important to use protection such as a dental dam (a piece of latex to cover the vagina during oral sex) or a condom. HIV can also be passed on through perinatal infection, where mothers who have HIV give the disease to the baby during birth. The risk of perinatal infection is declining with new treatments. Breastfeeding by an infected mother can also transmit HIV.
Once HIV enters the bloodstream, it takes over cells vital to the immune response, known as CD4+ lymphocytes. The virus then inserts its own genes into the cell, turning it into a miniature factory that produces more copies of the virus. Slowly, the amount of virus in the blood goes up, and the number of healthy CD4+ cells goes down. The destruction of CD4+ cells interferes with the body's ability to fight off infections, cancers, and other diseases.